Synthesis and in vitro evaluation of novel small molecule inhibitors of bacterial arylamine N-acetyltransferases (NATs).
The synthesis and inhibitory activity of a series of 5-substituted-(1,1-dioxo-2,3-dihydro-1H-1 lambda(6)-benzo[e][1,2]thiazin-4-ylidene)-thiazolidine-2,4-dione derivatives as competitive inhibitors of recombinant bacterial arylamine-N-acetyltransferases (NATs) are described. The most potent NAT inhi...
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Bibliographic Details
| Main Authors: |
Brooke, E,
Davies, S,
Mulvaney, A,
Okada, M,
Pompeo, F,
Sim, E,
Vickers, R,
Westwood, I |
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| Format: | Journal article
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| Language: | English |
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| Published: |
2003
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