A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

Misfolded glycoprotein recognition and endoplasmic reticulum (ER) retention are mediated by the ER glycoprotein folding quality control (ERQC) checkpoint enzyme, UDP-glucose glycoprotein glucosyltransferase (UGGT). UGGT modulation is a promising strategy for broad-spectrum antivirals, rescue-of-secr...

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Bibliographic Details
Main Authors:	Guay, KP, Ibba, R, Kiappes, JL, Vasiljević, S, Bonì, F, De Benedictis, M, Zeni, I, Le Cornu, JD, Hensen, M, Chandran, AV, Kantsadi, AL, Caputo, AT, Blanco Capurro, JI, Bayo, Y, Hill, JC, Hudson, K, Lia, A, Brun, J, Withers, SG, Martí, M, Biasini, E, Santino, A, De Rosa, M, Milani, M, Modenutti, CP, Hebert, DN, Zitzmann, N, Roversi, P
Format:	Journal article
Language:	English
Published:	Cell Press 2023

A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

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