C/EBPα and GATA-2 mutations induce bilineage acute erythroid leukemia through transformation of a neomorphic neutrophil-erythroid progenitor

C/EBPα and GATA-2 mutations induce bilineage acute erythroid leukemia through transformation of a neomorphic neutrophil-erythroid progenitor

Acute erythroid leukemia (AEL) commonly involves both myeloid and erythroid lineage transformation. However, the mutations that cause AEL and the cell(s) that sustain the bilineage leukemia phenotype remain unknown. We here show that combined biallelic Cebpa and Gata2 zinc finger-1 (ZnF1) mutations...

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מידע ביבליוגרפי
Main Authors: Di Genua, C, Valletta, S, Buono, M, Stoilova, B, Sweeney, C, Rodriguez-Meira, A, Grover, A, Meng, Y, Beveridge, R, Aboukhalil, Z, Karamitros, D, Belderbos, ME, Bystykh, L, Thongjuea, S, Vyas, P, Nerlov, C
פורמט: Journal article
שפה:English
יצא לאור: Cell Press 2020

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