Opposing effects of PKCtheta and WASp on symmetry breaking and relocation of the immunological synapse.

The immunological synapse (IS) is a junction between the T cell and antigen-presenting cell and is composed of supramolecular activation clusters (SMACs). No studies have been published on naive T cell IS dynamics. Here, we find that IS formation during antigen recognition comprises cycles of stable...

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Bibliographic Details
Main Authors: Sims, T, Soos, T, Xenias, H, Dubin-Thaler, B, Hofman, J, Waite, J, Cameron, T, Thomas, V, Varma, R, Wiggins, C, Sheetz, M, Littman, DR, Dustin, M
Format: Journal article
Language:English
Published: 2007