The effect of mutations in alpha-tropomyosin (E40K and E54K) that cause familial dilated cardiomyopathy on the regulatory mechanism of cardiac muscle thin filaments.

E40K and E54K mutations in alpha-tropomyosin cause inherited dilated cardiomyopathy. Previously we showed, using Ala-Ser alpha-tropomyosin (AS-alpha-Tm) expressed in Escherichia coli, that both mutations decrease Ca(2+) sensitivity. E40K also reduces V(max) of actin-Tm-activated S-1 ATPase by 18%. W...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Mirza, M, Robinson, P, Kremneva, E, Copeland, O, Nikolaeva, O, Watkins, H, Levitsky, D, Redwood, C, El-Mezgueldi, M, Marston, S
Format: Journal article
Język:English
Wydane: 2007