Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases.

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Cullin-RING ligases are multisubunit E3 ubiquitin ligases that recruit substrate-specific adaptors to catalyze protein ubiquitylation. Cul3-based Cullin-RING ligases are uniquely associated with BTB adaptors that incorporate homodimerization, Cul3 assembly, and substrate recognition into a single mu...

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Bibliographic Details
Main Authors: Canning, P, Cooper, C, Krojer, T, Murray, J, Pike, A, Chaikuad, A, Keates, T, Thangaratnarajah, C, Hojzan, V, Ayinampudi, V, Marsden, B, Gileadi, O, Knapp, S, von Delft, F, Bullock, A
Format: Journal article
Language:English
Published: 2013

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