Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

<p>Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for commonly-found <em>para</em>-substituted benzene rings in drug design<sup>1</sup>. The utility of these cage structures derives from their superior pharmacokinetic properties...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Frank, N, Nugent, J, Shire, BR, Pickford, HD, Rabe, P, Sterling, AJ, Zarganes-Tzitzikas, T, Grimes, T, Thompson, AL, Smith, RC, Schofield, CJ, Brennan, PE, Duarte, F, Anderson, EA
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	Springer Nature 2022

Ижил төстэй зүйлс

Synthesis of bicyclo[3.1.1]heptanes, meta-substituted arene isosteres, from [3.1.1]propellane
-н: Paul, B, зэрэг
Хэвлэсэн: (2025)

Synthesis and reactivity of [3.1.1]propellane
-н: Frank, N
Хэвлэсэн: (2022)

Computational supplementary material to the thesis "Synthesis and Reactivity of [3.1.1]Propellane"
-н: Frank, N
Хэвлэсэн: (2022)

The emerging role of radical chemistry in the amination transformation of highly strained [1.1.1]propellane: Bicyclo[1.1.1]pentylamine as bioisosteres of anilines
-н: Qiwen Pang, зэрэг
Хэвлэсэн: (2022-10-01)

Rationalizing the diverse reactivity of [1.1.1]propellane through sigma-pi-delocalization
-н: Sterling, AJ, зэрэг
Хэвлэсэн: (2020)

Insertion of [1.1.1]propellane into aromatic disulfides
-н: Robin M. Bär, зэрэг
Хэвлэсэн: (2019-05-01)

Reactivity of a spirobis(pentagerma[1.1.1]propellane)
-н: Lee Vladimir Ya., зэрэг
Хэвлэсэн: (2014-12-01)

Propellanes: structure and reactions/
-н: 258218 Ginsburg, David
Хэвлэсэн: (1975)

Synthesis of all-carbon disubstituted bicyclo[1.1.1]pentanes by iron-catalyzed Kumada cross-coupling
-н: Nugent, J, зэрэг
Хэвлэсэн: (2020)

A general route to bicyclo[1.1.1]pentanes through photoredox catalysis
-н: Nugent, J, зэрэг
Хэвлэсэн: (2019)

Strain-release transformations of bicyclo[1.1.0]butanes and [1.1.1]propellanes
-н: Qian-Qian Hu, зэрэг
Хэвлэсэн: (2024-03-01)

1,3-Difunctionalization of [1.1.1]propellane through iron-hydride catalyzed hydropyridylation
-н: Changha Kim, зэрэг
Хэвлэсэн: (2024-07-01)

Synthesis of all‐carbon disubstituted bicyclo[1.1.1]pentanes by iron‐catalyzed Kumada cross‐coupling
-н: Nugent, J, зэрэг
Хэвлэсэн: (2020)

Twofold radical-based synthesis of N,C-difunctionalized bicyclo[1.1.1]pentanes
-н: Pickford, HD, зэрэг
Хэвлэсэн: (2021)

Computational Modeling of the Feasibility of Substituted [1.1.1]Propellane Formation from Anionic Bridgehead Bromide Precursors
-н: Katherine E. Gates, зэрэг
Хэвлэсэн: (2023-05-01)

Bioisosteric similarity of drugs in virtual screening
-н: Hutter Michael C, зэрэг
Хэвлэсэн: (2010-05-01)

Synthesis of heterocycle-substituted bicyclo[3.1.1]heptanes and aza-bicyclo[3.1.1]heptanes via photocatalytic minisci reaction
-н: Revie, RI, зэрэг
Хэвлэсэн: (2024)

Catalytic methods for the synthesis of 1,3-disubstituted bicyclo[1.1.1]pentanes
-н: Shire, BR
Хэвлэсэн: (2022)

Synthesis of sulfur karrikin bioisosteres as potential neuroprotectives
-н: Martin Pošta, зэрэг
Хэвлэсэн: (2022-05-01)

Bioisosteres of Carbohydrate Functional Groups in Glycomimetic Design
-н: Rachel Hevey
Хэвлэсэн: (2019-07-01)

Synthesis of bioisosteric 5-sulfa-rutaecarpine derivatives
-н: Máté Bubenyák, зэрэг
Хэвлэсэн: (2010-11-01)

Extraction of useful bioisostere replacments from the PDB
-н: Ritschel T, зэрэг
Хэвлэсэн: (2011-04-01)

The use of phosphate bioisosteres in medicinal chemistry and chemical biology
-н: Elliott, T, зэрэг
Хэвлэсэн: (2012)

Carboxylic Acid Bioisosteres in Medicinal Chemistry: Synthesis and Properties
-н: Kato Bredael, зэрэг
Хэвлэсэн: (2022-01-01)

Inhibition of voltage-gated sodium channels by sumatriptan bioisosteres
-н: Roberta eCarbonara, зэрэг
Хэвлэсэн: (2015-07-01)

Conquering the synthesis and functionalization of bicyclo[1.1.1]pentanes
-н: Shire, BR, зэрэг
Хэвлэсэн: (2023)

Design, synthesis, and biological evaluation of (E)-2-benzylidene-1-indanones derivatized by bioisosteric replacement of aurones
-н: Youngshim Lee, зэрэг
Хэвлэсэн: (2024-12-01)

Virtual and experimental screening of new melatonin bioisosteres for the treatment of glaucoma
-н: D. A. Babkov, зэрэг
Хэвлэсэн: (2024-03-01)

Spectral Analysis on Cuba-Lumacaftor: Cubane as Benzene Bioisosteres of Lumacaftor
-н: Dongdong Wang, зэрэг
Хэвлэсэн: (2023-11-01)

BoBER: web interface to the base of bioisosterically exchangeable replacements
-н: Samo Lešnik, зэрэг
Хэвлэсэн: (2017-12-01)

Bioisosteric Replacement as a Tool in Anti-HIV Drug Design
-н: Alexej Dick, зэрэг
Хэвлэсэн: (2020-02-01)

Controlled oligomerization of [1.1.1]propellane through radical polarity matching: selective synthesis of SF5- and CF3SF4-containing [2]staffanes
-н: Jón Atiba Buldt, зэрэг
Хэвлэсэн: (2024-11-01)

Bridgehead vicinal diallylation of norbornene derivatives and extension to propellane derivatives via ring-closing metathesis
-н: Sambasivarao Kotha, зэрэг
Хэвлэсэн: (2016-08-01)

Synthesis of bis-oxathiaaza[3.3.3]propellanes via nucleophilic addition of (1,ω-alkanediyl)bis(N'-organylthioureas) on dicyanomethylene-1,3-indanedione
-н: Alaa A. Hassan, зэрэг
Хэвлэсэн: (2016-12-01)

Bioisosterism of Fluorine and Cyano as Indole Substituents. Theoretical, in vitro and in vivo Examination
-н: Timo Heinrich, зэрэг
Хэвлэсэн: (2004-03-01)

Craig plot 2.0: an interactive navigation in the substituent bioisosteric space
-н: Peter Ertl
Хэвлэсэн: (2020-01-01)

A phenotypic high-content, high-throughput screen identifies inhibitors of NLRP3 inflammasome activation
-н: Nizami, S, зэрэг
Хэвлэсэн: (2021)

Design and synthesis of propellane derivatives and oxa-bowls via ring-rearrangement metathesis as a key step
-н: Sambasivarao Kotha, зэрэг
Хэвлэсэн: (2015-09-01)

Titanium catalyzed [2σ + 2π] cycloaddition of bicyclo[1.1.0]-butanes with 1,3-dienes for efficient synthesis of stilbene bioisosteres
-н: Yonghong Liu, зэрэг
Хэвлэсэн: (2024-05-01)

Structural study of bioisosteric derivatives of 5-(1H-indol-3-yl)-benzotriazole and their ability to form chalcogen bonds
-н: Manon Mirgaux, зэрэг
Хэвлэсэн: (2022-04-01)