Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane

<p>Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for commonly-found&nbsp;<em>para</em>-substituted benzene rings in drug design<sup>1</sup>. The utility of these cage structures derives from their superior pharmacokinetic properties...

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Những tác giả chính: Frank, N, Nugent, J, Shire, BR, Pickford, HD, Rabe, P, Sterling, AJ, Zarganes-Tzitzikas, T, Grimes, T, Thompson, AL, Smith, RC, Schofield, CJ, Brennan, PE, Duarte, F, Anderson, EA
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: Springer Nature 2022

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