Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist

Cofactor mimicry represents an attractive strategy for the development of enzyme inhibitors but can lead to off-target effects due to the evolutionary conservation of binding sites across the proteome. Here, we uncover the ADP-ribose (ADPr) hydrolase NUDT5 as an unexpected, noncovalent, off-target o...

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Bibliographic Details
Main Authors:	Balıkçı, E, Marques, AMC, Bauer, LG, Seupel, R, Bennett, J, Raux, B, Buchan, K, Simelis, K, Singh, U, Rogers, C, Ward, J, Cheng, C, Szommer, T, Schützenhofer, K, Elkins, JM, Sloman, DL, Ahel, I, Fedorov, O, Brennan, PE, Huber, KVM
Format:	Journal article
Language:	English
Published:	American Chemical Society 2024

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist

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