Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.

Alcohol dependence is a common, complex and debilitating disorder with genetic and environmental influences. Here we show that alcohol consumption increases following mutations to the γ-aminobutyric acidA receptor (GABAAR) β1 subunit gene (Gabrb1). Using N-ethyl-N-nitrosourea mutagenesis on an alcoh...

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Bibliographic Details
Main Authors:	Anstee, Q, Knapp, S, Maguire, E, Hosie, A, Thomas, P, Mortensen, M, Bhome, R, Martinez, A, Walker, SE, Dixon, C, Ruparelia, K, Montagnese, S, Kuo, Y, Herlihy, A, Bell, J, Robinson, I, Guerrini, I, McQuillin, A, Fisher, E, Ungless, M, Gurling, H, Morgan, M, Brown, S, Stephens, D, Belelli, D
Format:	Journal article
Language:	English
Published:	Nature Publishing Group 2013

Mutations in the Gabrb1 gene promote alcohol consumption through increased tonic inhibition.

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