Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains.

BACKGROUND: There is widespread concern that H5N1 avian influenza A viruses will emerge as a pandemic threat, if they become capable of human-to-human (H2H) transmission. Avian strains lack this capability, which suggests that it requires important adaptive mutations. We performed a large-scale com...

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Bibliographic Details
Main Authors: Miotto, O, Heiny, A, Albrecht, R, Garcia-Sastre, A, Tan, T, August, J, Brusic, V
Format: Journal article
Language:English
Published: Public Library of Science 2010