Design, synthesis, and biological evaluation of enantiomeric beta-N-acetylhexosaminidase inhibitors LABNAc and DABNAc as potential agents against Tay-Sachs and Sandhoff disease.

Míreanna comhchosúla

• Efficient synthesis from D-lyxonolactone of 2-acetamido-1,4-imino-1,2,4-trideoxy-L-arabinitol LABNAc, a potent pyrrolidine inhibitor of hexosaminidases
  de réir: Rountree, J, et al.
  Foilsithe / Cruthaithe: (2007)
• Enantiomeric hexosaminidase inhibitors
  de réir: Rountree, J, et al.
  Foilsithe / Cruthaithe: (2005)
• Patient and caregiver perspectives on burden of disease manifestations in late-onset Tay-Sachs and Sandhoff diseases
  de réir: Nicole Lyn, et al.
  Foilsithe / Cruthaithe: (2020-04-01)
• Enantiomeric 2-acetamido-1,4-dideoxy-1,4-iminoribitols as potential pyrrolidine hexosaminidase inhibitors
  de réir: Rountree, J, et al.
  Foilsithe / Cruthaithe: (2011)
• An inducible mouse model of late onset Tay-Sachs disease.
  de réir: Jeyakumar, M, et al.
  Foilsithe / Cruthaithe: (2002)