KAT2-mediated acetylation switches the mode of PALB2 chromatin association to safeguard genome integrity
The tumour suppressor PALB2 stimulates RAD51-mediated homologous recombination (HR) repair of DNA damage, whilst its steady-state association with active genes protects these loci from replication stress. Here, we report that the lysine acetyltransferases 2A and 2B (KAT2A/2B, also called GCN5/PCAF),...
| Huvudupphovsmän: | , , , , , , , , , , , |
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| Materialtyp: | Journal article |
| Språk: | English |
| Publicerad: |
eLife Sciences Publications
2022
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