A UAF1-containing multisubunit protein complex regulates the Fanconi anemia pathway.

The deubiquitinating enzyme USP1 controls the cellular levels of the DNA damage response protein Ub-FANCD2, a key protein of the Fanconi anemia DNA repair pathway. Here we report the purification of a USP1 multisubunit protein complex from HeLa cells containing stoichiometric amounts of a WD40 repea...

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Bibliographic Details
Main Authors: Cohn, M, Kowal, P, Yang, K, Haas, W, Huang, T, Gygi, S, D'Andrea, A
Format: Journal article
Language:English
Published: 2007