9H-purine scaffold reveals induced-fit pocket plasticity of the BRD9 bromodomain
The 2-amine-9<em>H</em>-purine scaffold was identified as a weak bromodomain template and was developed via iterative structure based design into a potent nanomolar ligand for the bromodomain of human BRD9 with small residual micromolar affinity toward the bromodomain of BRD4. Binding of...
| Main Authors: | , , , , , , , , , |
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| 格式: | Journal article |
| 语言: | English |
| 出版: |
American Chemical Society
2015
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