Monosodium glutamate taste recognition thresholds are not affected by modulation of serotonin or noradrenaline levels in healthy humans
This study was designed to determine the effect of altering serotonin and noradrenaline levels on monosodium glutamate (MSG) taste recognition thresholds in humans. We have previously shown that manipulation of these neurotransmitters lowers taste thresholds of specific taste modalities (Heath et al...
| Päätekijät: | , , , , , , , , , |
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| Aineistotyyppi: | Conference item |
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AChemS
2009
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| _version_ | 1826269366208954368 |
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| author | Donaldson, L Heath, T Feakins, B Jones, N Kenyan, C Raichura, S Richardson, E Rooshenas, L Smith, V Melichar, J |
| author_facet | Donaldson, L Heath, T Feakins, B Jones, N Kenyan, C Raichura, S Richardson, E Rooshenas, L Smith, V Melichar, J |
| author_sort | Donaldson, L |
| collection | OXFORD |
| description | This study was designed to determine the effect of altering serotonin and noradrenaline levels on monosodium glutamate (MSG) taste recognition thresholds in humans. We have previously shown that manipulation of these neurotransmitters lowers taste thresholds of specific taste modalities (Heath et al 2006). A preliminary tongue map for MSG taste was generated in 34 healthy adults (6 male, 28 female, age range 19-71) to determine the most sensitive area of the tongue for further testing. In a further 26 adults (13 male, 13 female, age range 19-48) a series of MSG and sodium chloride solutions were presented either to the back or the tip of the tongue in a pseudorandom order. Recognition thresholds were calculated from psychophysical function curves before and 2 hours after a single acute dose of either paroxetine (serotonin selective reuptake inhibitor), reboxetine (noradrenaline reuptake inhibitor), caffeine (active placebo) or placebo (lactose) in a double blind cross-over design. MSG taste recognition thresholds were significantly lower at the back of the tongue compared to the tip (back 14±3mM, tip, 60±13mM, p<0.01). Comparison of thresholds at either the back or the tip of the tongue showed MSG recognition thresholds were not affected by any drug, or by placebo, in either region. Sodium chloride thresholds were also unaffected by any intervention, as previously shown. Thus, pharmacological modulation of serotonin or noradrenaline levels in humans has no effect on glutamate taste. These findings, together with our previous study showing that the same interventions modulate bitter and sweet taste, support a modality specific neuromodulatory role for serotonin and noradrenaline in human taste perception. |
| first_indexed | 2024-03-06T21:23:56Z |
| format | Conference item |
| id | oxford-uuid:42720b5a-0d4d-4b88-9b56-9191cf1d1cd9 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T21:23:56Z |
| publishDate | 2009 |
| publisher | AChemS |
| record_format | dspace |
| spelling | oxford-uuid:42720b5a-0d4d-4b88-9b56-9191cf1d1cd92022-03-26T14:49:27ZMonosodium glutamate taste recognition thresholds are not affected by modulation of serotonin or noradrenaline levels in healthy humansConference itemhttp://purl.org/coar/resource_type/c_5794uuid:42720b5a-0d4d-4b88-9b56-9191cf1d1cd9Symplectic Elements at OxfordAChemS2009Donaldson, LHeath, TFeakins, BJones, NKenyan, CRaichura, SRichardson, ERooshenas, LSmith, VMelichar, JThis study was designed to determine the effect of altering serotonin and noradrenaline levels on monosodium glutamate (MSG) taste recognition thresholds in humans. We have previously shown that manipulation of these neurotransmitters lowers taste thresholds of specific taste modalities (Heath et al 2006). A preliminary tongue map for MSG taste was generated in 34 healthy adults (6 male, 28 female, age range 19-71) to determine the most sensitive area of the tongue for further testing. In a further 26 adults (13 male, 13 female, age range 19-48) a series of MSG and sodium chloride solutions were presented either to the back or the tip of the tongue in a pseudorandom order. Recognition thresholds were calculated from psychophysical function curves before and 2 hours after a single acute dose of either paroxetine (serotonin selective reuptake inhibitor), reboxetine (noradrenaline reuptake inhibitor), caffeine (active placebo) or placebo (lactose) in a double blind cross-over design. MSG taste recognition thresholds were significantly lower at the back of the tongue compared to the tip (back 14±3mM, tip, 60±13mM, p<0.01). Comparison of thresholds at either the back or the tip of the tongue showed MSG recognition thresholds were not affected by any drug, or by placebo, in either region. Sodium chloride thresholds were also unaffected by any intervention, as previously shown. Thus, pharmacological modulation of serotonin or noradrenaline levels in humans has no effect on glutamate taste. These findings, together with our previous study showing that the same interventions modulate bitter and sweet taste, support a modality specific neuromodulatory role for serotonin and noradrenaline in human taste perception. |
| spellingShingle | Donaldson, L Heath, T Feakins, B Jones, N Kenyan, C Raichura, S Richardson, E Rooshenas, L Smith, V Melichar, J Monosodium glutamate taste recognition thresholds are not affected by modulation of serotonin or noradrenaline levels in healthy humans |
| title | Monosodium glutamate taste recognition thresholds are not affected by modulation of serotonin or noradrenaline levels in healthy humans |
| title_full | Monosodium glutamate taste recognition thresholds are not affected by modulation of serotonin or noradrenaline levels in healthy humans |
| title_fullStr | Monosodium glutamate taste recognition thresholds are not affected by modulation of serotonin or noradrenaline levels in healthy humans |
| title_full_unstemmed | Monosodium glutamate taste recognition thresholds are not affected by modulation of serotonin or noradrenaline levels in healthy humans |
| title_short | Monosodium glutamate taste recognition thresholds are not affected by modulation of serotonin or noradrenaline levels in healthy humans |
| title_sort | monosodium glutamate taste recognition thresholds are not affected by modulation of serotonin or noradrenaline levels in healthy humans |
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