The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.

The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions.

The metabolic reduction of 11-keto groups in glucocorticoid steroids such as cortisone leads to the nuclear receptor ligand cortisol. This conversion is an example of pre-receptor regulation and constitutes a novel pharmacological target for the treatment of metabolic disorders such as insulin resis...

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Bibliografiska uppgifter
Huvudupphovsmän:	Ogg, D, Elleby, B, Norström, C, Stefansson, K, Abrahmsén, L, Oppermann, U, Svensson, S
Materialtyp:	Journal article
Språk:	English
Publicerad:	2005

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