DOC-MEK: a double-blind randomized phase II trial of docetaxel with or without selumetinib in wild-type BRAF advanced melanoma.

DOC-MEK: a double-blind randomized phase II trial of docetaxel with or without selumetinib in wild-type BRAF advanced melanoma.

BACKGROUND: Treatment options for wild-type BRAF melanoma patients remain limited. Selumetinib, a MEK 1/2 inhibitor, suppresses pERK levels independent of BRAF and NRAS mutation status, and combination with docetaxel has demonstrated synergy in xenograft models. The aim of this study was to assess t...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Gupta, A, Love, S, Schuh, A, Shanyinde, M, Larkin, J, Plummer, R, Nathan, P, Danson, S, Ottensmeier, C, Lorigan, P, Collins, L, Wise, A, Asher, R, Lisle, R, Middleton, MR
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	Oxford University Press 2014

Antzeko izenburuak

DOC-MEK: A double-blind randomized phase II trial of docetaxel with or without selumetinib (AZD6244; ARRY-142886) in wt BRAF advanced melanoma
nork: Gupta, A, et al.
Argitaratua: (2013)

Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma
nork: Gupta, A, et al.
Argitaratua: (2020)

Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: A phase 2 double-blind randomised study
nork: Robert, C, et al.
Argitaratua: (2013)

Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study.
nork: Robert, C, et al.
Argitaratua: (2013)

Phase II, open-label, randomized trial of the MEK1/2 inhibitor selumetinib as monotherapy versus temozolomide in patients with advanced melanoma.
nork: Kirkwood, J, et al.
Argitaratua: (2012)

Improved survival with MEK inhibition in BRAF-mutated melanoma.
nork: Flaherty, K, et al.
Argitaratua: (2012)

Phase I trial of the MEK inhibitor selumetinib in combination with thoracic radiotherapy in non-small cell lung cancer
nork: K. Haslett, et al.
Argitaratua: (2021-05-01)

The MEK inhibitor selumetinib complements CTLA-4 blockade by reprogramming the tumor immune microenvironment
nork: Edmund Poon, et al.
Argitaratua: (2017-08-01)

Concurrent MEK2 Mutation and BRAF Amplification Confer Resistance to BRAF and MEK Inhibitors in Melanoma
nork: Jessie Villanueva, et al.
Argitaratua: (2013-09-01)

Immunological effects of BRAF+MEK inhibition
nork: Paolo A. Ascierto, et al.
Argitaratua: (2018-09-01)

Treatment with BRAF/MEK: inhibitors in mutant BRAF V600E papillary craniopharyngioma
nork: Eva Marie Erfurth, et al.
Argitaratua: (2024-12-01)

Exploring New Drug Repurposing Opportunities for MEK Inhibitors in RASopathies: A Comprehensive Review of Safety, Efficacy, and Future Perspectives of Trametinib and Selumetinib
nork: Andrea Gazzin, et al.
Argitaratua: (2024-06-01)

Identification of the Major Degradation Pathways of Selumetinib
nork: Tahar Sif eddine Bouchema, et al.
Argitaratua: (2022-11-01)

A phase I dose escalation study of the tolerability of the oral VEGFR and EGFR inhibitor vandetanib in combination with the oral MEK1/2 inhibitor selumetinib in solid tumors
nork: Pacey, S, et al.
Argitaratua: (2016)

Mutation analysis of BRAF, MEK1 and MEK2 in 15 ovarian cancer cell lines: implications for therapy.
nork: Anne L Estep, et al.
Argitaratua: (2007-12-01)

Response to BRAF/MEK Inhibition in A598_T599insV BRAF Mutated Melanoma
nork: Sara Bjursten, et al.
Argitaratua: (2019-11-01)

Management of BRAF and MEK inhibitor toxicities in patients with metastatic melanoma
nork: Sarah J. Welsh, et al.
Argitaratua: (2015-03-01)

Histological transformation to gliosarcoma with combined BRAF/MEK inhibition in BRAF V600E mutated glioblastoma
nork: Blessie Elizabeth Nelson, et al.
Argitaratua: (2023-05-01)

Effect of food on capsule and granule formulations of selumetinib
nork: Sarit Cohen‐Rabbie, et al.
Argitaratua: (2022-04-01)

Neuroprotective effect of selumetinib on acrolein-induced neurotoxicity
nork: Hui-Ju Huang, et al.
Argitaratua: (2021-06-01)

A phase I, open-label, randomized crossover study to assess the effect of dosing of the MEK 1/2 inhibitor Selumetinib (AZD6244; ARRY-142866) in the presence and absence of food in patients with advanced solid tumors
nork: Leijen, S, et al.
Argitaratua: (2011)

A phase I, open-label, randomized crossover study to assess the effect of dosing of the MEK 1/2 inhibitor Selumetinib (AZD6244; ARRY-142866) in the presence and absence of food in patients with advanced solid tumors.
nork: Leijen, S, et al.
Argitaratua: (2011)

Complete response with combined BRAF and MEK inhibition in BRAF mutated advanced low-grade serous ovarian carcinoma
nork: Bengt Tholander, et al.
Argitaratua: (2020-10-01)

BRAF and MEK Inhibitor Treatment for Metastatic Undifferentiated Sarcoma of the Spermatic Cord with BRAF V600E Mutation
nork: Ken Saijo, et al.
Argitaratua: (2022-08-01)

Autoimmunity associated with Erdheim-Chester disease improves with BRAF/MEK inhibitors
nork: Anaïs Roeser, et al.
Argitaratua: (2019-11-01)

Genetics-guided therapy in neuroendocrine carcinoma: response to BRAF- and MEK-inhibitors
nork: Lovisa Falkman, et al.
Argitaratua: (2024-04-01)

Comparison of responses of human melanoma cell lines to MEK and BRAF inhibitors
nork: Clare Judith Stones, et al.
Argitaratua: (2013-05-01)

Tolerability of BRAF/MEK inhibitor combinations: adverse event evaluation and management
nork: Jan Leipe, et al.
Argitaratua: (2019-06-01)

Case report: Metastatic BRAF V600E–mutated adult Wilms’ tumor with robust response to BRAF/MEK inhibitor therapy
nork: Matthew R. Kroll, et al.
Argitaratua: (2024-07-01)

Melanomas with concurrent BRAF non-p.V600 and NF1 loss-of-function mutations are targetable by BRAF/MEK inhibitor combination therapy
nork: Shivshankari Rajkumar, et al.
Argitaratua: (2022-04-01)

Efficacy of BRAF/MEK-inhibitor therapy for epithelioid glioblastoma with a novel BRAFV600 mutation
nork: J. Steininger, et al.
Argitaratua: (2024-08-01)

REPEATED USE OF BRAF AND MEK INHIBITORS IN METASTATIC MELANOMA PATIENTS AFTER PROFRESSION ON BRAF AND МЕК INHIBITORS. LITERATURE REVIEW AND CLINICAL OBSERVATION
nork: I. V. Samoylenko, et al.
Argitaratua: (2017-11-01)

Exceptional response to rechallenge of BRAF/MEK inhibitors in patients with primary acquired resistance to targeted therapy
nork: B. Ziółkowska, et al.
Argitaratua: (2024-01-01)

BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association
nork: Michael J. Vido, et al.
Argitaratua: (2018-11-01)

Combination therapy with BRAF and MEK inhibitors for melanoma: latest evidence and place in therapy
nork: Zeynep Eroglu, et al.
Argitaratua: (2016-01-01)

Multiple epidermotropic melanoma metastases developing during BRAF and MEK inhibitor therapy
nork: Raphael Reinhard, MD, et al.
Argitaratua: (2018-03-01)

A case of malignant transformation of a serous borderline ovarian tumor effectively treated with BRAF/MEK inhibitor combination
nork: Manrose Singh, et al.
Argitaratua: (2024-08-01)

Novel therapy: Combined BRAF and MEK inhibitors for locally advanced BRAF V600L–Positive mucosal melanoma in hypopharynx
nork: Sivakamavalli Jeyachandran
Argitaratua: (2024-06-01)

High BRAF V600 Mutation Level Associated with Worse Outcome in Metastatic Melanoma Patients Receiving BRAF and MEK Inhibitors
nork: Ariane Fizazi, et al.
Argitaratua: (2024-11-01)

ModraDoc006, an oral docetaxel formulation in combination with ritonavir (ModraDoc006/r), in metastatic castration‐resistant prostate cancer patients: A phase Ib study
nork: Marit A. C. Vermunt, et al.
Argitaratua: (2021-08-01)