Cardiac effects of antimalarial treatment with halofantrine.
In a prospective electrocardiographic study of Karen patients with acute uncomplicated falciparum malaria, mefloquine (25 mg/kg) had no cardiac effects (n = 53), but halofantrine (72 mg/kg) induced consistent dose-related lengthening of the PR and QT intervals in all 61 patients treated. The likelih...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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| _version_ | 1797065176420188160 |
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| author | Nosten, F ter Kuile, F Luxemburger, C Woodrow, C Kyle, D Chongsuphajaisiddhi, T White, N |
| author_facet | Nosten, F ter Kuile, F Luxemburger, C Woodrow, C Kyle, D Chongsuphajaisiddhi, T White, N |
| author_sort | Nosten, F |
| collection | OXFORD |
| description | In a prospective electrocardiographic study of Karen patients with acute uncomplicated falciparum malaria, mefloquine (25 mg/kg) had no cardiac effects (n = 53), but halofantrine (72 mg/kg) induced consistent dose-related lengthening of the PR and QT intervals in all 61 patients treated. The likelihood of significant QTc prolongation (by more than 25% or a QTc of 0.55 s1/2 or more) was greater after halofantrine as retreatment following mefloquine failure than as primary treatment (7/10 vs 18/51; relative risk 2.0 [95% Cl 1.1-3.4], p = 0.04). More than 60% of the effect occurred with three doses of halofantrine (24 mg/kg). The arrhythmogenic potential of halofantrine should now be investigated. |
| first_indexed | 2024-03-06T21:24:54Z |
| format | Journal article |
| id | oxford-uuid:42c27b38-d174-47b9-a2b0-c0dbbf9b2eaa |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T21:24:54Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:42c27b38-d174-47b9-a2b0-c0dbbf9b2eaa2022-03-26T14:51:21ZCardiac effects of antimalarial treatment with halofantrine.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:42c27b38-d174-47b9-a2b0-c0dbbf9b2eaaEnglishSymplectic Elements at Oxford1993Nosten, Fter Kuile, FLuxemburger, CWoodrow, CKyle, DChongsuphajaisiddhi, TWhite, NIn a prospective electrocardiographic study of Karen patients with acute uncomplicated falciparum malaria, mefloquine (25 mg/kg) had no cardiac effects (n = 53), but halofantrine (72 mg/kg) induced consistent dose-related lengthening of the PR and QT intervals in all 61 patients treated. The likelihood of significant QTc prolongation (by more than 25% or a QTc of 0.55 s1/2 or more) was greater after halofantrine as retreatment following mefloquine failure than as primary treatment (7/10 vs 18/51; relative risk 2.0 [95% Cl 1.1-3.4], p = 0.04). More than 60% of the effect occurred with three doses of halofantrine (24 mg/kg). The arrhythmogenic potential of halofantrine should now be investigated. |
| spellingShingle | Nosten, F ter Kuile, F Luxemburger, C Woodrow, C Kyle, D Chongsuphajaisiddhi, T White, N Cardiac effects of antimalarial treatment with halofantrine. |
| title | Cardiac effects of antimalarial treatment with halofantrine. |
| title_full | Cardiac effects of antimalarial treatment with halofantrine. |
| title_fullStr | Cardiac effects of antimalarial treatment with halofantrine. |
| title_full_unstemmed | Cardiac effects of antimalarial treatment with halofantrine. |
| title_short | Cardiac effects of antimalarial treatment with halofantrine. |
| title_sort | cardiac effects of antimalarial treatment with halofantrine |
| work_keys_str_mv | AT nostenf cardiaceffectsofantimalarialtreatmentwithhalofantrine AT terkuilef cardiaceffectsofantimalarialtreatmentwithhalofantrine AT luxemburgerc cardiaceffectsofantimalarialtreatmentwithhalofantrine AT woodrowc cardiaceffectsofantimalarialtreatmentwithhalofantrine AT kyled cardiaceffectsofantimalarialtreatmentwithhalofantrine AT chongsuphajaisiddhit cardiaceffectsofantimalarialtreatmentwithhalofantrine AT whiten cardiaceffectsofantimalarialtreatmentwithhalofantrine |