Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes

Mitotic centrosomes assemble when centrioles recruit large amounts of pericentriolar material (PCM) around themselves. The PCM comprises hundreds of proteins, and there is much debate about its physical nature. Here, we show that Drosophila Spd-2 (human CEP192) fluxes out from centrioles, recruiting...

Full description

Bibliographic Details
Main Authors: Wong, S-S, Monteiro, JM, Chang, C-C, Peng, M, Mohamad, N, Steinacker, TL, Xiao, B, Saurya, S, Wainman, A, Raff, JW
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2025