The antimalarial agent mefloquine inhibits ATP-sensitive K-channels.

The aim of this study was to determine whether antimalarial agents inhibit ATP-sensitive potassium (K(ATP)) channels and thereby contribute to the observed side-effects of these drugs. Mefloquine (10 - 100 microM), but not artenusate (100 microM), stimulated insulin release from pancreatic islets in...

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Bibliographic Details
Main Authors: Gribble, F, Davis, T, Higham, C, Clark, A, Ashcroft, F
Format: Journal article
Language:English
Published: 2000