Origin of de novo KCNJ11 mutations and risk of neonatal diabetes for subsequent siblings.
CONTEXT: Activating mutations in the KCNJ11 gene, which encodes the Kir6.2 subunit of the pancreatic beta-cell K(ATP) channel, result in permanent and transient neonatal diabetes. The majority of KCNJ11 mutations are spontaneous, but the parental origin of these mutations is not known. OBJECTIVE: O...
Main Authors: | , , , , , , , |
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Format: | Journal article |
Language: | English |
Published: |
2007
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