Association of the tumour necrosis factor alpha -308 but not the interleukin 10 -627 promoter polymorphism with genetic susceptibility to primary sclerosing cholangitis.

BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology. Abnormalities in immune regulation and genetic associations suggest that PSC is an immune mediated disease. Several polymorphisms within the tumour necrosis factor alpha (TNF-alpha...

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Bibliographic Details
Main Authors: Mitchell, SA, Grove, J, Spurkland, A, Boberg, K, Fleming, K, Day, C, Schrumpf, E, Chapman, R
Format: Journal article
Language:English
Published: 2001