Structure of HLA-A*0301 in complex with a peptide of proteolipid protein: insights into the role of HLA-A alleles in susceptibility to multiple sclerosis.

The structure of the human major histocompatability (MHC) class I molecule HLA-A*0301 (HLA-A3) in complex with a nonameric peptide (KLIETYFSK) has been determined by X-ray crystallography to 2.7 Å resolution. HLA-A3 is a predisposing allele for multiple sclerosis (MS), an autoimmune disease of the c...

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Những tác giả chính: McMahon, R, Friis, L, Siebold, C, Friese, M, Fugger, L, Jones, E
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2011