The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
The cofactor tetrahydrobiopterin (BH4) is required for nitric oxide (NO) production by all nitric oxide synthase (NOS) enzymes and is a key regulator of cellular redox signalling. When BH4 levels become limiting NOS enzymes become 'uncoupled' and produce superoxide rather than NO. Endothel...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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