Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury.

Glycosphingolipid depletion in PC12 cells using iminosugars protects neuronal membranes from anti-ganglioside antibody mediated injury.

Autoimmune neuropathies are frequently associated with pathogenic anti-ganglioside antibodies targeting ganglioside-rich neuronal and glial membranes. The extent of injury is determined by the concentration of membrane ganglioside and thus reduction might be expected to attenuate disease. In this st...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs:	Townson, K, Speak, A, Greenshields, K, Goodyear, C, Willison, H, Platt, F
Formaat:	Journal article
Taal:	English
Gepubliceerd in:	2008

Gelijkaardige items

Ganglioside antibodies and neuropathies.
door: Rinaldi, S, et al.
Gepubliceerd in: (2008)

Multi-system disorders of glycosphingolipid and ganglioside metabolism
door: You-Hai Xu, et al.
Gepubliceerd in: (2010-07-01)

Correction of liver steatosis by a hydrophobic iminosugar modulating glycosphingolipids metabolism.
door: Elisa Lombardo, et al.
Gepubliceerd in: (2012-01-01)

Characterization and quantitative determination of gangliosides and neutral glycosphingolipids in human liver.
door: O Nilsson, et al.
Gepubliceerd in: (1982-02-01)

Glycosphingolipids in endocytic membrane transport.
door: Sillence, D, et al.
Gepubliceerd in: (2004)

Generalized accumulation of neutral glycosphingolipids with GM2 ganglioside accumulation in the brain
door: Paul D. Snyder, Jr., et al.
Gepubliceerd in: (1972-01-01)

A rapid and quantitative method for the isolation of gangliosides and neutral glycosphingolipids by DEAE-silica gel chromatography.
door: S K Kundu, et al.
Gepubliceerd in: (1978-03-01)

Iminosugar-based inhibitors of glucosylceramide synthase increase brain glycosphingolipids and survival in a mouse model of Sandhoff disease.
door: Karen M Ashe, et al.
Gepubliceerd in: (2011-01-01)

Diverse endogenous antigens for mouse NKT cells: self-antigens that are not glycosphingolipids.
door: Pei, B, et al.
Gepubliceerd in: (2011)

New GM1 Ganglioside Derivatives for Selective Single and Double Labelling of the Natural Glycosphingolipid Skeleton
door: Polyakova, S, et al.
Gepubliceerd in: (2009)

Iminosugar inhibitors for treating the lysosomal glycosphingolipidoses
door: Butters, T, et al.
Gepubliceerd in: (2005)

Introduction: Glycosphingolipids in cell biology and disease.
door: Sillence, D, et al.
Gepubliceerd in: (2004)

Glycosphingolipid antigens from Leishmania (L.) amazonensis amastigotes: Binding of anti-glycosphingolipid monoclonal antibodies in vitro and in vivo
door: A.H. Straus, et al.
Gepubliceerd in: (1997-03-01)

[Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function].
door: Porubsky, S, et al.
Gepubliceerd in: (2008)

Glycosphingolipids Gb3 and iGb3. In vivo roles in hemolytic-uremic syndrome and iNKT cell function
door: Porubsky, S, et al.
Gepubliceerd in: (2008)

Substrate reduction therapy for glycosphingolipid storage disorders.
door: Lachmann, R, et al.
Gepubliceerd in: (2001)

A Novel Iminosugar UV-12 with Activity against the Diverse Viruses Influenza and Dengue (Novel Iminosugar Antiviral for Influenza and Dengue)
door: Kelly L. Warfield, et al.
Gepubliceerd in: (2015-05-01)

Regulation of membrane-bound enzymes of glycosphingolipid biosynthesis
door: J D Burczak, et al.
Gepubliceerd in: (1984-12-01)

Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides
door: Pan, X, et al.
Gepubliceerd in: (2017)

Glycosphingolipid dysregulation and lysosomal dysfunction in motor neuron disease
door: da Silva Santos, CS
Gepubliceerd in: (2021)

Glycosphingolipid lysosomal storage diseases: therapy and pathogenesis.
door: Jeyakumar, M, et al.
Gepubliceerd in: (2002)

Anti-ganglioside antibodies and celiac disease
door: Alessandro Granito, et al.
Gepubliceerd in: (2021-05-01)

The relationship between depletion of brain GM1 ganglioside and Parkinson's disease
door: Sandro Sonnino
Gepubliceerd in: (2023-09-01)

New therapeutics for the treatment of glycosphingolipid lysosomal storage diseases.
door: Butters, T, et al.
Gepubliceerd in: (2003)

Inhibition of glycosphingolipid biosynthesis: application to lysosomal storage disorders.
door: Butters, T, et al.
Gepubliceerd in: (2000)

New developments in treating glycosphingolipid storage diseases.
door: Platt, F, et al.
Gepubliceerd in: (2005)

Iminosugar for treatment of tumors
door: Dwek, R, et al.
Gepubliceerd in: (2008)

Glycosphingolipid metabolism and its role in ageing and Parkinson’s disease
door: Wallom, K-L, et al.
Gepubliceerd in: (2021)

Altered expression of ganglioside metabolizing enzymes results in GM3 ganglioside accumulation in cerebellar cells of a mouse model of juvenile neuronal ceroid lipofuscinosis
door: Somogyi, A, et al.
Gepubliceerd in: (2018)

Ultrasound-mediated piezoelectric differentiation of neuron-like PC12 cells on PVDF membranes
door: Marcus Hoop, et al.
Gepubliceerd in: (2017-06-01)

Iminosugar antivirals: the therapeutic sweet spot
door: Alonzi, D, et al.
Gepubliceerd in: (2017)

Identification of GM1-Ganglioside Secondary Accumulation in Fibroblasts from Neuropathic Gaucher Patients and Effect of a Trivalent Trihydroxypiperidine Iminosugar Compound on Its Storage Reduction
door: Costanza Ceni, et al.
Gepubliceerd in: (2024-01-01)

Iminosugars: promising therapeutics for influenza infection
door: Tyrrell, B, et al.
Gepubliceerd in: (2016)

Profile in ganglioside antibodies in benign prostatic hyperplasia
door: Ilinca Nicolae, et al.
Gepubliceerd in: (2016-03-01)

ALTERED AUTOPHAGY AND APP METABOLISM IN GLYCOSPHINGOLIPID STORAGE DISEASES
door: Boland, B, et al.
Gepubliceerd in: (2011)

The mechanism of action of iminosugars as antiretrovirals
door: Spiro, S, et al.
Gepubliceerd in: (2014)

The synthesis and biology of iminosugars and their precursors
door: Ayers, B, et al.
Gepubliceerd in: (2014)

The synthesis of branched sugars and iminosugars
door: Parry, LL
Gepubliceerd in: (2011)

Total asymmetric syntheses of iminosugars
door: Figuccia, A, et al.
Gepubliceerd in: (2015)

Substrate deprivation: a new therapeutic approach for the glycosphingolipid lysosomal storage diseases.
door: Platt, F, et al.
Gepubliceerd in: (2000)