Evolution of PHDs as oxygen sensors: mechanistic and structural studies of the PHD of Trichoplax adhaerens, the simplest animal, and mechanistic studies of a PHD-like enzyme of the protist Monosiga brevicollis

<p>This work aimed to investigate the evolutionary origin of the involvement of the HIF Prolyl Hydroxylases (PHDs) in oxygen sensing. The α/β-heterodimer HIF (<u>H</u>ypoxia <u>I</u>nducible <u>F</u>actor) is a master regulator of oxygen homoeostasis in meta...

Täydet tiedot

Bibliografiset tiedot
Päätekijä: Boleininger, A
Muut tekijät: Schofield, C
Aineistotyyppi: Opinnäyte
Kieli:English
Julkaistu: 2012
Aiheet: