Enantioconvergent alkylation of ketones with racemic secondary alcohols via hydrogen borrowing catalysis

An enantioconvergent method for the alkylation of o-disubstituted aryl ketones with racemic secondary alcohols is described. This process is mediated by a commercially available iridium catalyst and proceeds via hydrogen borrowing catalysis. The highly enantioenriched β-substituted ketone products w...

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Príomhchruthaitheoirí: Cheang, DMJ, Armstrong, RJ, Akhtar, WM, Donohoe, TJ
Formáid: Journal article
Teanga:English
Foilsithe / Cruthaithe: Royal Society of Chemistry 2020