A genome-wide association study of IVGTT-based measures of first phase insulin secretion refines the underlying physiology of Type 2 Diabetes variants.

<p>Understanding the physiological mechanisms by which common variants predispose to type 2 diabetes requires large studies with detailed measures of insulin secretion and sensitivity. Here we performed the largest genome-wide association study of first phase insulin secretion, as measured by...

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Main Authors:	Wood, A, Jonsson, A, Jackson, A, Wang, N, van Leewen, N, Palmer, N, Kobes, S, Deelen, J, Boquete-Vilarino, L, Paananen, J, Stančáková, A, Boomsma, D, de Geus, E, Eekhoff, E, Fritsche, A, Kramer, M, Nijpels, G, Simonis-Bik, A, van Haeften, T, Mahajan, A, Boehnke, M, Bergman, R, Tuomilehto, J, Collins, F, Mohlke, K, Banasik, K, Groves, C, McCarthy, M, Pearson, E, Natali, A, Mari, A, Buchanan, T, Taylor, K, Xiang, A, Gjesing, A, Grarup, N, Eiberg, H, Pedersen, O, Chen, Y, Laakso, M, Norris, J, Smith, U, Wagenknecht, L, Baier, L, Bowden, D, Hansen, T, Walker, M, Watanabe, R, 't Hart, L, Hanson, R, Frayling, T
Format:	Journal article
Language:	English
Published:	American Diabetes Association 2017

A genome-wide association study of IVGTT-based measures of first phase insulin secretion refines the underlying physiology of Type 2 Diabetes variants.

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