Granulocyte-Macrophage Colony-Stimulating Factor Regulates Effector Differentiation of Invariant Natural Killer T Cells during Thymic Ontogeny

Eitemau Tebyg

• Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny
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• Nur77 controls tolerance induction, terminal differentiation, and effector functions in semi-invariant natural killer T cells
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• Cutting Edge: The Ontogeny and Function of Va14Ja18 Natural T Lymphocytes Require Signal Processing by Protein Kinase Cθ and NF-κB
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  Cyhoeddwyd: (2004)
• Nur77 controls tolerance induction, terminal differentiation, and effector functions in NKT cells
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  Cyhoeddwyd: (2020)
• Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions.
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