Stimulation of mononuclear cells through Toll-like receptor 9 induces release of microvesicles expressing double-stranded DNA and galectin 3-binding protein in an interferon-α-dependent manner
Background: Microvesicles (MVs) expressing the type 1 interferon (IFN)-inducible protein galectin-3 binding protein (G3BP) may play a pathogenic role in systemic lupus erythematosus (SLE). Co-expression of double-stranded DNA (dsDNA) on such MVs may render them immunogenic and targets for anti-dsDNA...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Frontiers Media
2019
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