Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation
<p style="text-align:justify;"> Loss of iRhom2, a catalytically inactive rhomboid‐like protein, blocks maturation of TACE/ADAM17 in macrophages, resulting in defective shedding of the cytokine tumor necrosis factor. Apart from the resulting inflammatory defects, iRhom2‐null mice app...
| Main Authors: | , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
EMBO Press
2013
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