Selective P450BM3 hydroxylation of cyclobutylamine and bicyclo[1.1.1]pentylamine derivatives: underpinning synthetic chemistry for drug discovery

Achieving single-step syntheses of a set of related compounds divergently and selectively from a common starting material affords substantial efficiency gains when compared with preparing those same compounds by multiple individual syntheses. In order for this approach to be realized, complementary...

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Bibliographic Details
Main Authors: Harwood, L, Xiong, Z, Christensen, K, Wang, R, Wong, L, Robertson, J
Format: Journal article
Language:English
Published: American Chemical Society 2023