A small molecule inhibitor of PDK1/PLCγ1 interaction blocks breast and melanoma cancer cell invasion

Strong evidence suggests that phospholipase Cγ1 (PLCγ1) is a suitable target to counteract tumourigenesis and metastasis dissemination. We recently identified a novel signalling pathway required for PLCγ1 activation which involves formation of a protein complex with 3-phosphoinositide-dependent prot...

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Bibliographic Details
Main Authors: Potter, B, Raimondi, C, Calleja, V, Ferro, R, Fantin, A, Riley, A, Brennan, C, Maffucci, T, Larijani, B, Falasca, M
Format: Journal article
Published: Nature Publishing Group 2016