A small molecule inhibitor of PDK1/PLCγ1 interaction blocks breast and melanoma cancer cell invasion
Strong evidence suggests that phospholipase Cγ1 (PLCγ1) is a suitable target to counteract tumourigenesis and metastasis dissemination. We recently identified a novel signalling pathway required for PLCγ1 activation which involves formation of a protein complex with 3-phosphoinositide-dependent prot...
Main Authors: | , , , , , , , , , |
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Format: | Journal article |
Published: |
Nature Publishing Group
2016
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