Amide analogues of CD1d agonists modulate iNKT-cell-mediated cytokine production.

Invariant natural killer T (iNKT) cells are restricted by the non-polymorphic MHC class I-like protein, CD1d, and activated following presentation of lipid antigens bound to CD1d molecules. The prototypical iNKT cell agonist is α-galactosyl ceramide (α-GalCer). CD1d-mediated activation of iNKT cells...

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Detalles Bibliográficos
Autores principales: Wojno, J, Jukes, J, Ghadbane, H, Shepherd, D, Besra, G, Cerundolo, V, Cox, L
Formato: Journal article
Lenguaje:English
Publicado: 2012