Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.

Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.

The possession of some HLA class I molecules is associated with delayed progression to AIDS. The mechanism behind this beneficial effect is unclear. We tested the idea that cytotoxic T-cell responses restricted by advantageous HLA class I molecules impose stronger selection pressures than those rest...

Полное описание

Библиографические подробности
Главные авторы: Frater, A, Brown, H, Oxenius, A, Günthard, H, Hirschel, B, Robinson, N, Leslie, A, Payne, R, Crawford, H, Prendergast, A, Brander, C, Kiepiela, P, Walker, B, Goulder, P, McLean, A, Phillips, R
Формат: Journal article
Язык:English
Опубликовано: 2007

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