Vertical T cell immunodominance and epitope entropy determine HIV-1 escape.

HIV-1 accumulates mutations in and around reactive epitopes to escape recognition and killing by CD8+ T cells. Measurements of HIV-1 time to escape should therefore provide information on which parameters are most important for T cell-mediated in vivo control of HIV-1. Primary HIV-1-specific T cell...

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Bibliographic Details
Main Authors:	Liu, M, Hawkins, N, Ritchie, A, Ganusov, V, Whale, V, Brackenridge, S, Li, H, Pavlicek, J, Cai, F, Rose-Abrahams, M, Treurnicht, F, Hraber, P, Riou, C, Gray, C, Ferrari, G, Tanner, R, Ping, L, Anderson, J, Swanstrom, R, Cohen, M, Karim, S, Haynes, B, Borrow, P, Perelson, A, Shaw, G
Format:	Journal article
Language:	English
Published:	2013

Vertical T cell immunodominance and epitope entropy determine HIV-1 escape.

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