Scalable syntheses of both enantiomers of DNJNAc and DGJNAc from glucuronolactone: the effect of N-alkylation on hexosaminidase inhibition.

The efficient scalable syntheses of 2-acetamido-1,2-dideoxy-D-galacto-nojirimycin (DGJNAc) and 2-acetamido-1,2-dideoxy-D-gluco-nojirimycin (DNJNAc) from D-glucuronolactone, as well as of their enantiomers from L-glucuronolactone, are reported. The evaluation of both enantiomers of DNJNAc and DGJNAc,...

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Bibliographic Details
Main Authors: Glawar, A, Best, D, Ayers, B, Miyauchi, S, Nakagawa, S, Aguilar-Moncayo, M, García Fernández, J, Ortiz Mellet, C, Crabtree, E, Butters, T, Wilson, F, Kato, A, Fleet, G
Format: Journal article
Language:English
Published: 2012