Structural fuzziness of the RNA-organizing protein SERF determines a toxic gain-of-interaction
The mechanisms by which protein complexes convert from functional into pathogenic are the subject of intensive research. Here, we report how functionally unfavourable protein interactions can be induced by structural fuzziness, i.e. by persisting conformational disorder in protein complexes. We show...
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2019
|