Heterogeneity and dynamics in the assembly of the heat shock protein 90 chaperone complexes.

The Hsp90 cycle depends on the coordinated activity of a range of cochaperones, including Hop, Hsp70 and peptidyl-prolyl isomerases such as FKBP52. Using mass spectrometry, we investigate the order of addition of these cochaperones and their effects on the stoichiometry and composition of the result...

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Autori principali: Ebong, I, Morgner, N, Zhou, M, Saraiva, M, Daturpalli, S, Jackson, SE, Robinson, C
Natura: Journal article
Lingua:English
Pubblicazione: 2011