Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

<p><strong>Background</strong> We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinat...

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Bibliographic Details
Main Authors:	Matuozzo, D, Talouarn, E, Marchal, A, Zhang, P, Manry, J, Seeleuthner, Y, Zhang, Y, Bolze, A, Chaldebas, M, Milisavljevic, B, Gervais, A, Bastard, P, Asano, T, Bizien, L, Barzaghi, F, Abolhassani, H, Abou Tayoun, A, Aiuti, A, Alavi Darazam, I, Allende, LM, Alonso-Arias, R, Arias, AA, Aytekin, G, Bergman, P, Bondesan, S, Bryceson, YT, Bustos, IG, Cabrera-Marante, O, Carcel, S, Carrera, P, Casari, G, Chaïbi, K, Colobran, R, Condino-Neto, A, Covill, LE, Delmonte, OM, El Zein, L, Flores, C, Gregersen, PK, Gut, M, Haerynck, F, Halwani, R, Hancerli, S, Hammarström, L, Hatipoğlu, N, Karbuz, A, Keles, S, Kyheng, C, Leon-Lopez, R, Franco, JL, Constantinescu, SN
Other Authors:	COVID Human Genetic Effort
Format:	Journal article
Language:	English
Published:	BioMed Central 2023

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

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