The phenylmethylthiazolylthiourea nonnucleoside reverse transcriptase (RT) inhibitor MSK-076 selects for a resistance mutation in the active site of human immunodeficiency virus type 2 RT.
The phenylmethylthiazolylthiourea (PETT) derivative MSK-076 shows, besides high potency against human immunodeficiency virus type 1 (HIV-1), marked activity against HIV-2 (50% effective concentration, 0.63 microM) in cell culture. Time-of-addition experiments pointed to HIV-2 reverse transcriptase (...
Автори: | Auwerx, J, Stevens, M, Van Rompay, A, Bird, L, Ren, J, De Clercq, E, Oberg, B, Stammers, D, Karlsson, A, Balzarini, J |
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Формат: | Journal article |
Мова: | English |
Опубліковано: |
2004
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