Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in development. Cholesterol influences Hh signaling...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Luchetti, G, Sircar, R, Kong, J, Nachtergaele, S, Sagner, A, Byrne, E, Covey, D, Siebold, C, Rohatgi, R
स्वरूप: Journal article
भाषा:English
प्रकाशित: eLife Sciences Publications 2016