Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling

Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in development. Cholesterol influences Hh signaling...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς:	Luchetti, G, Sircar, R, Kong, J, Nachtergaele, S, Sagner, A, Byrne, E, Covey, D, Siebold, C, Rohatgi, R
Μορφή:	Journal article
Γλώσσα:	English
Έκδοση:	eLife Sciences Publications 2016

Παρόμοια τεκμήρια

Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
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Έκδοση: (2016-10-01)

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Multiple ligand binding sites regulate the Hedgehog signal transducer Smoothened in vertebrates
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Έκδοση: (2017)

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Structures of vertebrate Patched and Smoothened reveal intimate links between cholesterol and Hedgehog signalling
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Έκδοση: (2019)

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Έκδοση: (2013-10-01)

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Cholesterol accessibility at the ciliary membrane controls hedgehog signaling
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Structure‐Activity Relationship Studies of Hydantoin‐Cored Ligands for Smoothened Receptor
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Έκδοση: (2021-10-01)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
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Έκδοση: (2018-12-01)

Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma
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Έκδοση: (2019-12-01)

Clobetasol and Halcinonide Act as Smoothened Agonists to Promote Myelin Gene Expression and RxRγ Receptor Activation.
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Έκδοση: (2015-01-01)

Cyclopamine modulates smoothened receptor activity in a binding position dependent manner
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In silico studies on smoothened human receptor and its antagonists in search of anticancer effects
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Έκδοση: (2020-01-01)

Linear and nonlinear approach for DEM smoothening
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Έκδοση: (2006-01-01)

Linear and nonlinear approach for DEM smoothening
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Mechanisms of Smoothened Regulation in Hedgehog Signaling
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Έκδοση: (2021-08-01)

Hrs promotes ubiquitination and mediates endosomal trafficking of smoothened in Drosophila hedgehog signaling.
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Limitations of Smoothening Functions for Automotive Vibro-Impact Problems
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Έκδοση: (2011-01-01)

Deciphering the Allosteric Effect of Antagonist Vismodegib on Smoothened Receptor Deactivation Using Metadynamics Simulation
ανά: Xiaoli An, κ.ά.
Έκδοση: (2019-06-01)

A Smoothening Method for the Piecewise Linear Interpolation
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Biochemical mechanisms of vertebrate hedgehog signaling
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Έκδοση: (2019)

Data analysis of molecular dynamics simulation trajectories of β-sitosterol, sonidegib and cholesterol in smoothened protein with the CHARMM36 force field
ανά: Mohammad Tasyriq Che Omar
Έκδοση: (2020-12-01)