Cholesterol activates the G-protein coupled receptor Smoothened to promote morphogenetic signaling
Cholesterol is necessary for the function of many G-protein coupled receptors (GPCRs). We find that cholesterol is not just necessary but also sufficient to activate signaling by the Hedgehog (Hh) pathway, a prominent cell-cell communication system in development. Cholesterol influences Hh signaling...
| Hauptverfasser: | , , , , , , , , |
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| Format: | Journal article |
| Sprache: | English |
| Veröffentlicht: |
eLife Sciences Publications
2016
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