Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria

Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria

<p>Sequestration of infected erythrocytes during P. falciparum infection can lead to severe malaria. PfEMP1 proteins are central to this process. Multimodular PfEMP1 proteins can bind to a variety of human ligands due to the presence of CIDR and DBL domains. CIDR and DBL domains are classified...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awdur:	Ng, HK
Awduron Eraill:	Higgins, M
Fformat:	Traethawd Ymchwil
Iaith:	English
Cyhoeddwyd:	2012
Pynciau:	Molecular biophysics (biochemistry)

Eitemau Tebyg

PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes.
gan: Horrocks, P, et al.
Cyhoeddwyd: (2005)

Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
gan: Tuju, J, et al.
Cyhoeddwyd: (2019)

Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
gan: James Tuju, et al.
Cyhoeddwyd: (2019-07-01)

Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed
gan: Barfod, L, et al.
Cyhoeddwyd: (2015)

Identifying genetic determinants of impaired PfEMP1 export in Plasmodium falciparum-infected erythrocytes
gan: Neal, AT
Cyhoeddwyd: (2014)

Correction: Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
gan: PLOS Pathogens Staff
Cyhoeddwyd: (2019-08-01)

Characterisation of the naturally occurring antibody response to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) [MIM-cm-190904]
gan: Mackintosh, C, et al.
Cyhoeddwyd: (2005)

The kinetics of antibody binding to <it>Plasmodium falciparum </it>VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs
gan: Arnot David E, et al.
Cyhoeddwyd: (2010-04-01)

Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells.
gan: Myriam Baratin, et al.
Cyhoeddwyd: (2007-01-01)

Improvement of Plasmodium Falciparum erythrocyte membrane protein-1 (PfEMP-1) vaccine antigens using directed molecular evolution
gan: Heinrichs, V, et al.
Cyhoeddwyd: (2005)

A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in <it>Plasmodium falciparum </it>infected erythrocytes
gan: Arnot David E, et al.
Cyhoeddwyd: (2008-06-01)

Genome mapping of malaria resistance genes: the host ligands of PfEMP1
gan: Fry, A
Cyhoeddwyd: (2009)

PfEMP1 is the major target of antibodies to the surface of P-falciparum-infected erythrocytes that are associated with protection from malaria.
gan: Howell, K, et al.
Cyhoeddwyd: (2008)

PfEMP1, polymorphism and pathogenesis.
gan: Newbold, C, et al.
Cyhoeddwyd: (1997)

Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1.
gan: Kirsten Moll, et al.
Cyhoeddwyd: (2015-01-01)

Interaction Analysis of a Plasmodium falciparum PHISTa-like Protein and PfEMP1 Proteins
gan: Baoling Yang, et al.
Cyhoeddwyd: (2020-11-01)

Structural analysis of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) intracellular domain reveals a conserved interaction epitope.
gan: Mayer, C, et al.
Cyhoeddwyd: (2012)

Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface
gan: Maria del Pilar Quintana, et al.
Cyhoeddwyd: (2018-02-01)

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes.
gan: Liz Stevenson, et al.
Cyhoeddwyd: (2015-07-01)

Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains.
gan: Frankland, S, et al.
Cyhoeddwyd: (2006)

Correction: Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1.
gan: Kirsten Moll, et al.
Cyhoeddwyd: (2016-01-01)

Plasmodium falciparum PHIST proteins contribute to cytoadherence and anchor PfEMP1 to the host cell cytoskeleton
gan: Oberli, A, et al.
Cyhoeddwyd: (2016)

Optimized Purification of CIDRα-PfEMP1 Plasmodium falciparum Recombinant Protein with Affinity Chromatography
gan: Eqiel Navadz Akthar Alami, et al.
Cyhoeddwyd: (2022-07-01)

Differential PfEMP1 expression is associated with cerebral malaria pathology.
gan: Dumizulu L Tembo, et al.
Cyhoeddwyd: (2014-12-01)

Plasmodium falciparum rosetting epitopes converge in the SD3-loop of PfEMP1-DBL1α.
gan: Davide Angeletti, et al.
Cyhoeddwyd: (2012-01-01)

Plasmodium falciparum antigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria.
gan: Abdi, A, et al.
Cyhoeddwyd: (2014)

Var Gene Encoding Duffy-Binding Like (DBL) 1α- Plasmodium Falciparum Erythrocyte Membrane Protein 1 (PfEMP1) as Diagnostic Marker and Clinical Predictor Candidates for Falciparum Malaria
gan: Rosita Dewi, et al.
Cyhoeddwyd: (2024-12-01)

Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1.
gan: Louise Joergensen, et al.
Cyhoeddwyd: (2010-09-01)

Plasmodium falciparum PfEMP1 modulates monocyte/macrophage transcription factor activation, and cytokine and chemokine responses
gan: Sampaio, N, et al.
Cyhoeddwyd: (2017)

Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria
gan: Jo-Anne Chan, et al.
Cyhoeddwyd: (2019-01-01)

Sequence variation of PfEMP1-DBLα in association with rosette formation in <it>Plasmodium falciparum </it>isolates causing severe and uncomplicated malaria
gan: Craig Alister, et al.
Cyhoeddwyd: (2009-08-01)

Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes.
gan: Micheline Guillotte, et al.
Cyhoeddwyd: (2015-01-01)

Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.
gan: Ghumra, A, et al.
Cyhoeddwyd: (2011)

Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.
gan: Ashfaq Ghumra, et al.
Cyhoeddwyd: (2011-01-01)

Recombinant DBL2β-PfEMP1 of the Indonesian Plasmodium falciparum induces immune responses in Wistar rats
gan: Sheilla Rachmania, M.Biotech, et al.
Cyhoeddwyd: (2021-06-01)

Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers.
gan: Louise Turner, et al.
Cyhoeddwyd: (2011-01-01)

B-cell epitopes in NTS-DBL1α of PfEMP1 recognized by human antibodies in Rosetting Plasmodium falciparum.
gan: Letusa Albrecht, et al.
Cyhoeddwyd: (2014-01-01)

<it>var </it>gene transcription and PfEMP1 expression in the rosetting and cytoadhesive <it>Plasmodium falciparum </it>clone FCR3S1.2
gan: Chen Qijun, et al.
Cyhoeddwyd: (2011-01-01)

THE CIDR1α-PfEMP1 SEQUENCE FROM INDONESIAN PLASMODIUM FALCIPARUM AND ITS POTENTIAL ASSOCIATION WITH THE CEREBRAL OUTCOME
gan: Erma Sulistyaningsih, et al.
Cyhoeddwyd: (2021-01-01)

<named-content content-type="genus-species">Plasmodium falciparum</named-content>-Infected Erythrocyte Knob Density Is Linked to the PfEMP1 Variant Expressed
gan: Ramesh Subramani, et al.
Cyhoeddwyd: (2015-10-01)