Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria

Structural characterisation of the interaction between Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and their human ligands in severe malaria

<p>Sequestration of infected erythrocytes during P. falciparum infection can lead to severe malaria. PfEMP1 proteins are central to this process. Multimodular PfEMP1 proteins can bind to a variety of human ligands due to the presence of CIDR and DBL domains. CIDR and DBL domains are classified...

Deskribapen osoa

Xehetasun bibliografikoak
Egile nagusia:	Ng, HK
Beste egile batzuk:	Higgins, M
Formatua:	Thesis
Hizkuntza:	English
Argitaratua:	2012
Gaiak:	Molecular biophysics (biochemistry)

Antzeko izenburuak

PfEMP1 expression is reduced on the surface of knobless Plasmodium falciparum infected erythrocytes.
nork: Horrocks, P, et al.
Argitaratua: (2005)

Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1)
nork: Tuju, J, et al.
Argitaratua: (2019)

Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
nork: James Tuju, et al.
Argitaratua: (2019-07-01)

Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed
nork: Barfod, L, et al.
Argitaratua: (2015)

Identifying genetic determinants of impaired PfEMP1 export in Plasmodium falciparum-infected erythrocytes
nork: Neal, AT
Argitaratua: (2014)

Correction: Antigenic cartography of immune responses to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1).
nork: PLOS Pathogens Staff
Argitaratua: (2019-08-01)

Characterisation of the naturally occurring antibody response to Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) [MIM-cm-190904]
nork: Mackintosh, C, et al.
Argitaratua: (2005)

The kinetics of antibody binding to <it>Plasmodium falciparum </it>VAR2CSA PfEMP1 antigen and modelling of PfEMP1 antigen packing on the membrane knobs
nork: Arnot David E, et al.
Argitaratua: (2010-04-01)

Dissection of the role of PfEMP1 and ICAM-1 in the sensing of Plasmodium-falciparum-infected erythrocytes by natural killer cells.
nork: Myriam Baratin, et al.
Argitaratua: (2007-01-01)

Improvement of Plasmodium Falciparum erythrocyte membrane protein-1 (PfEMP-1) vaccine antigens using directed molecular evolution
nork: Heinrichs, V, et al.
Argitaratua: (2005)

A method for visualizing surface-exposed and internal PfEMP1 adhesion antigens in <it>Plasmodium falciparum </it>infected erythrocytes
nork: Arnot David E, et al.
Argitaratua: (2008-06-01)

Genome mapping of malaria resistance genes: the host ligands of PfEMP1
nork: Fry, A
Argitaratua: (2009)

PfEMP1 is the major target of antibodies to the surface of P-falciparum-infected erythrocytes that are associated with protection from malaria.
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Argitaratua: (2008)

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Argitaratua: (1997)

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Argitaratua: (2015-01-01)

Interaction Analysis of a Plasmodium falciparum PHISTa-like Protein and PfEMP1 Proteins
nork: Baoling Yang, et al.
Argitaratua: (2020-11-01)

Structural analysis of the Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) intracellular domain reveals a conserved interaction epitope.
nork: Mayer, C, et al.
Argitaratua: (2012)

Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface
nork: Maria del Pilar Quintana, et al.
Argitaratua: (2018-02-01)

α2-Macroglobulin Can Crosslink Multiple Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) Molecules and May Facilitate Adhesion of Parasitized Erythrocytes.
nork: Liz Stevenson, et al.
Argitaratua: (2015-07-01)

Delivery of the malaria virulence protein PfEMP1 to the erythrocyte surface requires cholesterol-rich domains.
nork: Frankland, S, et al.
Argitaratua: (2006)

Correction: Evasion of Immunity to Plasmodium falciparum: Rosettes of Blood Group A Impair Recognition of PfEMP1.
nork: Kirsten Moll, et al.
Argitaratua: (2016-01-01)

Plasmodium falciparum PHIST proteins contribute to cytoadherence and anchor PfEMP1 to the host cell cytoskeleton
nork: Oberli, A, et al.
Argitaratua: (2016)

Optimized Purification of CIDRα-PfEMP1 Plasmodium falciparum Recombinant Protein with Affinity Chromatography
nork: Eqiel Navadz Akthar Alami, et al.
Argitaratua: (2022-07-01)

Differential PfEMP1 expression is associated with cerebral malaria pathology.
nork: Dumizulu L Tembo, et al.
Argitaratua: (2014-12-01)

Plasmodium falciparum rosetting epitopes converge in the SD3-loop of PfEMP1-DBL1α.
nork: Davide Angeletti, et al.
Argitaratua: (2012-01-01)

Plasmodium falciparum antigenic variation: relationships between widespread endothelial activation, parasite PfEMP1 expression and severe malaria.
nork: Abdi, A, et al.
Argitaratua: (2014)

Var Gene Encoding Duffy-Binding Like (DBL) 1α- Plasmodium Falciparum Erythrocyte Membrane Protein 1 (PfEMP1) as Diagnostic Marker and Clinical Predictor Candidates for Falciparum Malaria
nork: Rosita Dewi, et al.
Argitaratua: (2024-12-01)

Surface co-expression of two different PfEMP1 antigens on single plasmodium falciparum-infected erythrocytes facilitates binding to ICAM1 and PECAM1.
nork: Louise Joergensen, et al.
Argitaratua: (2010-09-01)

Plasmodium falciparum PfEMP1 modulates monocyte/macrophage transcription factor activation, and cytokine and chemokine responses
nork: Sampaio, N, et al.
Argitaratua: (2017)

Low Levels of Human Antibodies to Gametocyte-Infected Erythrocytes Contrasts the PfEMP1-Dominant Response to Asexual Stages in P. falciparum Malaria
nork: Jo-Anne Chan, et al.
Argitaratua: (2019-01-01)

Sequence variation of PfEMP1-DBLα in association with rosette formation in <it>Plasmodium falciparum </it>isolates causing severe and uncomplicated malaria
nork: Craig Alister, et al.
Argitaratua: (2009-08-01)

Immunogenicity of the Plasmodium falciparum PfEMP1-VarO Adhesin: Induction of Surface-Reactive and Rosette-Disrupting Antibodies to VarO Infected Erythrocytes.
nork: Micheline Guillotte, et al.
Argitaratua: (2015-01-01)

Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.
nork: Ghumra, A, et al.
Argitaratua: (2011)

Immunisation with recombinant PfEMP1 domains elicits functional rosette-inhibiting and phagocytosis-inducing antibodies to Plasmodium falciparum.
nork: Ashfaq Ghumra, et al.
Argitaratua: (2011-01-01)

Recombinant DBL2β-PfEMP1 of the Indonesian Plasmodium falciparum induces immune responses in Wistar rats
nork: Sheilla Rachmania, M.Biotech, et al.
Argitaratua: (2021-06-01)

Antibodies against PfEMP1, RIFIN, MSP3 and GLURP are acquired during controlled Plasmodium falciparum malaria infections in naïve volunteers.
nork: Louise Turner, et al.
Argitaratua: (2011-01-01)

B-cell epitopes in NTS-DBL1α of PfEMP1 recognized by human antibodies in Rosetting Plasmodium falciparum.
nork: Letusa Albrecht, et al.
Argitaratua: (2014-01-01)

<it>var </it>gene transcription and PfEMP1 expression in the rosetting and cytoadhesive <it>Plasmodium falciparum </it>clone FCR3S1.2
nork: Chen Qijun, et al.
Argitaratua: (2011-01-01)

THE CIDR1α-PfEMP1 SEQUENCE FROM INDONESIAN PLASMODIUM FALCIPARUM AND ITS POTENTIAL ASSOCIATION WITH THE CEREBRAL OUTCOME
nork: Erma Sulistyaningsih, et al.
Argitaratua: (2021-01-01)

<named-content content-type="genus-species">Plasmodium falciparum</named-content>-Infected Erythrocyte Knob Density Is Linked to the PfEMP1 Variant Expressed
nork: Ramesh Subramani, et al.
Argitaratua: (2015-10-01)