Activation of the unfolded protein response in high glucose treated endothelial cells is mediated by methylglyoxal

Metabolic dysfunction of endothelial cells in hyperglycemia contributes to the development of vascular complications of diabetes where increased reactive glycating agent, methylglyoxal (MG), is involved. We assessed if increased MG glycation induced proteotoxic stress, identifying related metabolic...

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Autori principali: Irshad, Z, Xue, M, Ashour, A, Larkin, JR, Thornalley, PJ, Rabbani, N
Natura: Journal article
Lingua:English
Pubblicazione: Springer Nature 2019