Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells
Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we use a mouse model of human neonatal diabetes to show that chronic hyperglycemia impairs glucose metabolism and alters expre...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal article |
| Published: |
Nature Publishing Group
2016
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