Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Insulin secretion from pancreatic β-cells is impaired in all forms of diabetes. The resultant hyperglycaemia has deleterious effects on many tissues, including β-cells. Here we use a mouse model of human neonatal diabetes to show that chronic hyperglycemia impairs glucose metabolism and alters expre...

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Bibliographic Details
Main Authors:	Brereton, M, Rohm, M, Shimomura, K, Holland, C, Tornovsky-Babeay, S, Dadon, D, Iberl, M, Chibalina, M, Lee, S, Glaser, B, Dor, Y, Rorsman, P, Clark, A, Ashcroft, F
Format:	Journal article
Published:	Nature Publishing Group 2016

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